A total of 8 OI-related genes were identified, and mutations in COL1A1 (denosumab: 11/25, 44.0%; zoledronic acid: 12/26, 46.2%) and COL1A2 (denosumab: 8/25, 32.0%; zoledronic acid: 8/26, 30.8%) were the most common, which were classified as AD inheritance. Here, COL1A1 is linked to Alzheimer disease.