The distribution of macrophage M0 in breast cancer tissues is positively correlated with VEGF and MVD, which promotes breast cancer progression by regulating angiogenesis in breast cancer.[18] Studies also have shown that macrophage M0 may reduce the sensitivity of breast cancer cells to chemotherapeutic drugs by producing interleukin 10.[19] A previous study treated breast cancer cells with a macrophage M0 culture medium supernatant. The gene discussed is VEGFA; the disease is breast cancer.