CXCL12 and neoplasm: In IMPC tumor cells, the membrane-bound C-X-C chemokine receptor type 4(CXCR4) and stromal cell-derived factor-1(SDF-1)on lymphatic endothelial cell interaction is a pivotal step in lymphatic metastasis.[29] Furthermore, the loss of AT-Rich Interaction Domain 1A(ARID1A) expression is significantly associated with ten-year Overall Survival (OS) and disease-free survival, particularly in the Luminal B subgroup.[33] Lan et al[34] conducted in-depth research on plakoglobin role in IMPC, which is notably overexpressed when compared to IDC-NSTs.