A few prominent markers for IMPC are mucin-1 glycoprotein (MUC1) and epithelial membrane antigen (EMA), while KL-6(Krebs Von den Lungen-6)has also been reported in breast cancer cases.[30] Since Annexin A2 (ANX A2) is recognized as a cellular polarity protein involved in lumen formation, its disrupted functionality results in impaired anti-apoptotic effects and increased apoptosis in tumor cells displaying ANX A2 membrane accumulation.[22] Subsequently, such events trigger polarity disruption which generates detached tumor cells. This evidence concerns the gene MUC1 and breast cancer.