Urinary NGAL is a predictive biomarker of acute kidney injury, a substance produced by excessive induction and expression of renal tubular epithelium.[15] Although Brunner·HI demonstrated that levels of NGAL are associated with activity in LN, due to research limitations, it is not certain whether urinary NGAL can predict early activity in LN.[16,17] We expect this conclusion to be confirmed in future studies. This evidence concerns the gene LCN2 and acute kidney injury.