DNMT1 and rheumatoid arthritis: Some research suggests that 5’-AZA-mediated demethylation of the interleukin-10 (IL-10) gene may inhibit the development of RA by enhancing the production of the immunosuppressive IL-10.[31] Additionally, a novel DNMT inhibitor called SGI-1027, a lipophilic, quinoline-based compound, has been identified.