APC and colorectal carcinoma: Furthermore, the development of CRC follows a temporal sequence, wherein chromosomal instability and prevalent oncogene mutations must transpire subsequent to the APC gene mutation in order to instigate CRC.[19] Hence, the direct impact of short telomeres on chromosomal instability may be insufficient to induce polyp development whereas the elongation of telomeres leading to prolonged cell division times may heighten the likelihood of genetic mutations, thereby contributing to the development of polyps.