ACE and cardiac sarcoidosis: Second, clinical evidence of cardiac involvement has been reported in only 5% of patients with sarcoidosis.[4] Third, although serum ACE levels have been associated with the occurrence of sarcoidosis, the prevalence of elevated ACE levels in patients with sarcoidosis has been reported to be only 21.8%, indicating the absence of sensitive markers available to predict sarcoidosis.[39] Fourth, the histologic diagnostic rate of cardiac sarcoidosis was inadequate.