ITGA4 and neoplasm: In circulating CD8+ T cells from patients whose tumor achieved pCR, there was higher expression of cell adhesion molecules (CD62L, CCR8, CD49d, CD18), as well as TIGIT (which was also increased in intratumoral CD8+ T cells in pCR versus non-pCR pre-sotigalimab; Supplementary Fig. S5A).