TP53 and non-small cell lung carcinoma: Studies have found that theabrownin (TB) is a pigment active substance in green tea, which has the ability to phosphorylate and activate MAPK/JNK pathway-related proteins, and at the same time inhibit epithelial-mesenchymal transition-related genes and pro-apoptotic molecules, p53 signaling pathway and MAPK/JNK signaling pathway, thereby effectively inhibiting the growth of NSCLC cells in xenograft models [8].