NFKB1 and neoplasm: Meanwhile, several studies have also revealed that tumorigenesis-related signaling pathways, such as PI3K/Akt, Wnt/β-catenin, and NF-κB, are closely related to the activity of SIRT, and that alterations in SIRT activity may affect the activation pathways of these pathways, thereby promoting the process of tumor cellular development [68–70].