In addition to the tumor microenvironment, analyses of data from The Cancer Genome Atlas database show distinctive molecular aberrations in ILC compared with IDC, such as E-cadherin loss (66% vs. 3%), FOXA1 mutations (7% vs. 2%), and GATA3 mutations (5% vs. 20%) [17, 18]. The gene discussed is FOXA1; the disease is neoplasm.