Therefore, the present study aimed to examine the potential augmented antidepressant effects of combining vitamins C and D with escitalopram and to encompass a comprehensive scrutiny of NOx, Nrf2, BDNF, and HO-1 expressions in both the hippocampus and frontal cortex in an LPS-induced depression mice model. The gene discussed is NFE2L2; the disease is major depressive disorder.