Abbreviations; Aβ – Amyloid-β, ACE – Addenbrooke’s Cognitive Examination, AD – Alzheimer’s Disease, ALAT – Alanine transaminase, p-tau – Phosphorylated tau, CRP – C-reactive protein, CSF – Cerebrospinal fluid, FAQ – Functional Activities Questionnaire, GFAP – Glial fibrillary acidic protein, HDL – High-density lipoprotein, LDH – Lactate dehydrogenase, LDL – Low-density protein, MMSE – Mini-Mental State Examination, Nf-L – Neurofilament light, SD – Standard deviation, SIMOA – Single molecule array, t-tau – Total tau. Here, ACE is linked to early-onset autosomal dominant Alzheimer disease.