In the context of organoid tissue culture, researchers previously fabricated iPSC‐derived liver tissue with knockdown of SIRT1 and demonstrated that SIRT1 deficiency induced fatty liver disease—the authors noted that this model, though partially successful, lacked important features of non‐alcoholic steatohepatitis in humans such as (a) increased collagen deposition and (b) changes to metabolic zonation. This evidence concerns the gene SIRT1 and fatty liver disease.