SMARCA4 and non-small cell lung carcinoma: All cancer cell lines harbouring frame shift or nonsense mutations in SMARCA4 showed reduced SMARCA4 mRNA and protein abundance (Fig. 1C; Supplementary Fig. S1B), consistent with the SMARCA4 “class 1 alterations” observed in non–small cell lung carcinoma (NSCLC; ref. 27).