Moreover, GSEA was used to further investigate the biological functions of the 7 real hub genes in lung cancer and the results indicated that the high expression groups of FXR1, ESR1, KIT, MCL1, BCL2L11, and HIF1A were significantly enriched in the pathways associated with cell proliferation, such as IL6/JAK/STAT3 and PI3K/AKT/mTOR signaling pathway. The gene discussed is ESR1; the disease is lung cancer.