Functional annotation analysis showed that the 10 hub genes significantly enriched in GO terms were related to apoptosis and RNA transcription, such as regulation of intrinsic apoptotic signaling pathway, regulation of apoptotic process, regulation of programmed cell death, Bcl-2 family protein complex, and RNA strand annealing activity, which are implicated in the regulation of cell growth in lung cancer [57, 58]. This evidence concerns the gene BCL2 and lung carcinoma.