The results showed that the mRNA expression levels of ESR1 (Figure 6A), DDX3X (Figure 6C), MAPK10 (Figure 6D), KIT (Figure 6F), FOXO1 (Figure 6I), and MCL1 (Figure 6J) were significantly lower in both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tissues (p < 0.001) than normal lung tissues. This evidence concerns the gene ESR1 and squamous cell lung carcinoma.