Specific to lung cancer, the alteration frequency of the seven hub genes was 20% for FXR1, 19% for KRAS, 2.7% for ESR1, 6% for KIT, 8% for MCL1, 0.8% for BCL2L11, and 1.7% for HIF1A (Figure 9B). This evidence concerns the gene HIF1A and lung carcinoma.