GSEA analysis manifested three cancer-related pathways (Cell cycle, Wnt signaling pathway, and Mismatch repair) and three immune-related pathways (Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, and PD-L1 expression and PD-1 checkpoint pathway) that might be regulated by OXS-clusters, providing insights for exploring the mechanism of the clustering system for OS (Figure 2A). The gene discussed is CD274; the disease is cancer.