However, CYP7A1 KO mice show that inhibition of CYP7A1 does not result in hypercholesterolemia as cholesterol is eliminated by their secretion into bile by the cholesterol transporter ATP-binding cassette transporter G (ABCG5) and G8 (ABCG8) [18,78]. The gene discussed is CYP7A1; the disease is Hypercholesterolemia.