We successfully discovered the potential role, mechanism and key targets of Aloin A against CC-induced muscle atrophy by using network pharmacology, molecular docking, molecular dynamics and experimental validation, and found that Aloin A realizes the therapeutic effect of cancer cachexia through multiple targets and pathways, including HSP90AA1/AKT signaling, which provides evidence for Aloin A as a potential drug for the treatment of cancer cachexia in a clinic. The gene discussed is AKT1; the disease is cancer.