These studies establish a role for Dystroglycan function at a subset of inhibitory synapses in the brain, but the critical features of Dystroglycan necessary for these functions, and the relationship between inhibitory synaptogenesis and neurological phenotypes in dystroglycanopathy, remains undefined. The gene discussed is DAG1; the disease is neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan.