Dystroglycan is a central component of the dystrophin-glycoprotein complex (DGC) known primarily for its role in the etiology of neuromuscular diseases including Duchenne muscular dystrophy (DMD), limb-girdle muscular dystrophy (LGMD), and congenital muscular dystrophy (CMD). This evidence concerns the gene ART4 and Duchenne muscular dystrophy.