It has also been shown previously that PGE2 is induced in human PBECs during viral infections and is involved in regulating the antiviral host response.21,43 In the current study, we found that RV16 infection increased PTGS2 expression in cultures from non-asthmatic donors and that PTGS-dependent biosynthesis of PGE2 was significantly increased in AA supplemented cultures. The gene discussed is PTGS2; the disease is viral infectious disease.