LH3 is essential for normal biosynthesis and secretion of type IV Cols50 into the basement membrane, and both these proteins have been implicated in vascular diseases, including Ehlers-Danlos syndrome, which is associated with aneurysm and vessel rupture (Online Mendelian Inheritance in Man [OMIM] 612394).49 Our study suggests that loss of basement membrane integrity may also be a key feature of vascular aging, increasing the susceptibility of the vessel to structural failure. The gene discussed is PLOD3; the disease is Ehlers-Danlos syndrome.