Beyond its role in malignancies, emerging research suggests that PIK3CA also plays a critical role in benign fibrotic diseases: it has been observed that PIK3CA drives prostatic stromal hypertrophy and collagen accumulation in a mouse model, while PIK3CA deficiency reduces myocardial fibrosis by inhibiting the PI3K/AKT signaling pathway [9,10]. This evidence concerns the gene PIK3CA and Myocardial fibrosis.