TLR7 and influenza: Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (BBIQ) is a potential TLR7 agonist, and it was shown that recombinant influenza HA protein vaccine administered with BBIQ significantly enhanced anti-influenza IgG1 and IgG2c response in mice (Kaushik et al., 2020), suggesting BBIQ as a promising influenza vaccine adjuvant for further study.