Intellectual disability-7 (MRD7 OMIM#614104) is caused by mutations in DYRK1A, which is an autosomal dominant hereditary disorder of autism and generally characterized by autism, intellectual disability (ID) features which cause primary microcephaly (−3 SD), nonverbal severe intellectual and physical disability, anxious behavior, and deformities. The gene discussed is DYRK1A; the disease is autism.