In MR Egger, the p-values of MR Egger intercepts in each instrumental variable of Glycemic Traits were greater than 0.05, suggesting that the intercept does not exist, indicating fasting There was no horizontal pleiotropy for Fasting Glucose, 2-h Glucose, Fasting Insulin, HbA1c, and Type-2 Diabetes (Table 3). The gene discussed is INS; the disease is type 2 diabetes mellitus.