Studies by Zeng et al. (2018) [27], Zheng et al. (2020) [28], Zheng et al. (2021) [29], Zhu et al. (2015) [30], and Zhu et al. (2017) [31] repeatedly indicated higher TNF-α in DPN patients, underlining its potential function as a biomarker and contributor to diabetic neuropathy. The gene discussed is TNF; the disease is diabetic neuropathy.