ASPG and acute lymphoblastic leukemia: The standard induction treatment options in America for newly diagnosed childhood ALL include chemotherapy; the following agents are used with or without an anthracycline (either doxorubicin or daunorubicin): VCR, corticosteroid (prednisone or dexamethasone), asparaginase (pegaspargase, calaspargase pegol, asparaginase Erwinia chrysanthemi and native Escherichia coli L-asparaginase (unavailable in the US), and intrathecal chemotherapy [2,3,45].