The clinical diagnostic of hyperthyroidism is straightforward, but the question to be answered in front of any case of hyperthyroidism despite overt or subclinical stage of disease, is whether there is a case with an overproduction of thyroid hormones when antithyroid medication is considered (2), respectively there is a destructive case, in which the control of inflammation/aggression is mandatory. This evidence concerns the gene TG and hyperthyroidism.