In addition to the combination of certain medications discussed above, there are numerous other dual-combination approaches for the treatment of T2D, including combinations of alpha glucosidase inhibitors and DPP-4 inhibitors (94), SGLT2 inhibitors and GLP-1 receptor agonists (95), etc. These combined medication strategies could help to further lower blood glucose levels and achieve better diabetes management and treatment. This evidence concerns the gene DPP4 and type 2 diabetes mellitus.