In addition, we evaluated additional potential members of the anti-inflammatory TLR4/TRIF signaling pathway, including transcription factor cellular musculoaponeurotic fibrosarcoma (c-Maf), phosphorylated protein kinase B (pAkt), heat shock protein 70 (HSP70), and pCREB, in tissue lysates obtained from the amygdala and NAc of male and female P rats following the administration of 3α,5α-THP or vehicle control. The gene discussed is TLR4; the disease is fibrosarcoma.