Genes associated with T lymphocyte function, CD3D (CD3 delta subunit of T-cell receptor complex), CD3E (CD3 epsilon subunit of T-cell receptor complex), CD8B (CD8 beta subunit), LCK (LCK proto-oncogene, SRC family tyrosine kinase), and ZAP70 (zeta chain of T-cell receptor-associated protein kinase 70kDa), are underexpressed in HPV-positive HNCs and cervical cancers. The gene discussed is CD3E; the disease is cervical cancer.