CTLA4 and neoplasm: In tumor tissue, TGFB synthesis leads to overexpression of CTLA4/CD152, with depletion of T lymphocytes (184), which begin to release inhibitory molecules, including PD1, CTLA4, TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains) and LAG3 (Lymphocyte Activating 3), which reduce their activity and production of cytokines and cytolytic molecules (185).