Thus, Stich and collaborators reported that the demethylating agent 5-aza-2’-deoxycytidine can reduce E6 and E7 gene expression in HPV-infected HNCs and cervical cell lines effectively, with some restoration of TP53 and P21 function and increased tumor suppressor microRNA 375 levels, contributing to overall decrease in cancer cell growth and survival (165). Here, TP53 is linked to cancer.