TRAF1 and cancer: Also, Hinic and collaborators identified overexpression of PCNA (proliferating cell nuclear antigen) genes, associated with cell proliferation and transformation in cancer, TNFRSF14 (TNF receptor superfamily member 14), which promotes inflammatory and inhibitory T cell immune response, TRAF1 (TNF receptor-associated factor 1), TRAF2 (TNF receptor-associated factor 2), which mediate anti-apoptotic and pro-survival signals from TNF receptors, BIRC3 (baculoviral IAP repeat containing 3) and BCL2 (B-cell lymphoma 2), with anti-apoptotic functions (130).