IFNA1 and viral infectious disease: Autoantibodies against type I IFNs are present in approximately 0.17% to 1.1% of the general population <70 years old [2], indicating that their generation during a lifetime is a rare event and may be associated with acute viral infections, systemic inflammatory events, or chronic type I IFN exposure (eg, in patients with IFN-based anticancer therapy) [6].