To further characterize the cell-specific influence of P2RY2 function in the pathogenesis of ARDS, we conducted the experiments with conditional P2ry2fl/fl mice crossed with LysM-Cre animals (macrophages/neutrophils), CD4-Cre animals (CD4+ cells) and CCT-Cre animals (airway epithelial cells). This evidence concerns the gene CD4 and acute respiratory distress syndrome.