Peli1 activates the AKT pathway and is involved in various biological and pathological processes, including cancer progression (23, 103), drug resistance (104), angiogenesis (96, 100, 105), T follicular helper (Tfh) cell differentiation (93), microglia activation (98), glycolysis, and macrophage M1 polarization (31). This evidence concerns the gene PELI1 and cancer.