PELI1 and Sepsis: A novel membrane-bound palmitate-coupled Smad6-derived peptide called Smaducin-6 has been developed to disrupt IRAK1-, RIP1-, and Ikkε-mediated TLR4 signaling complex formation by interacting with membrane-bound Peli1 and to restore neutrophil recruitment by reducing GRK2 expression in neutrophils through CXCR2 re-expression is sepsis (87).