A study focusing on the Bcl-6-dependent risk stratification of DLBCL based on Peli1 nuclear expression highlighted the potential role of Peli1 and Bcl-6 in assessing DLBCL risk (125) Peli1 expression is highly elevated in high-grade lymphomas but significantly reduced in low-grade lymphomas (124). This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.