We have called the condition of non-PCOS “simple” obesity in association with relative, uncompensated hypogonadotropic hypogonadism “reprometabolic syndrome.” To attempt to isolate factors that could contribute to the aberrant hormonal milieu in women with high BMI, we examined gonadotropin dynamics in normal-weight women administered either insulin, lipid infusion, or both and compared these to a saline infusion (19). This evidence concerns the gene INS and Obesity.