A previous study demonstrated that RES treatment protected high-fat diet (HFD)-induced insulin resistance (IR) rats from diet-induced IR and elevated the expression of sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), mitochondrial DNA, and mitochondrial biogenesis (Haohao et al., 2015). This evidence concerns the gene SIRT1 and Insulin resistance.