AKT1 and ischemic disease: Transplantation of MSCs transfected with miR-126 has been shown to improve angiogenesis in the vascular endotheliocytes of ischemic diseases through the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathways [46].