The expression level of BIN2, GAPT, and NUDT4 decreased significantly in the AD cohort (log2foldchange < −10), with SASH1 and RGPD8 expressing a notable upregulation in the AD cohort (log2foldchange > 10) (Figures 3B, D) compared to the CNC cohort. Here, GAPT is linked to Alzheimer disease.