Following DT treatment, a decline in tumor control correlated with the depletion of PD-1+IRF4.GFP+, Tim-3+IRF4.GFP+, and TIGIT+IRF4.GFP+ CD8+ TILs, indicating that these markers denote activated and functional TILs in this context. The gene discussed is HAVCR2; the disease is neoplasm.