In summary, we identified 13 ferroptosis-related genes (DRD5, TSC22D3, TFAP2A, STMN1, DDIT3, MYCN, ELAVL1, JUN, DUSP1, MIB1, PSAT1, LCE2C, and MIR27A) as the target genes induced by CPAP therapy (1 year) in the patient with OSA. This evidence concerns the gene DRD5 and obstructive sleep apnea syndrome.