In summary, we identified 13 ferroptosis-related genes (DRD5, TSC22D3, TFAP2A, STMN1, DDIT3, MYCN, ELAVL1, JUN, DUSP1, MIB1, PSAT1, LCE2C, and MIR27A) as the target genes induced by CPAP therapy (1 year) in the patient with OSA. This evidence concerns the gene TSC22D3 and obstructive sleep apnea syndrome.