In conjunction with RNA-seq and microarray data, ARL4C exhibited significantly elevated expression levels in the metastasis of esophageal carcinoma (ESCA), oral carcinoma, THCA, colon adenocarcinoma (COAD), kidney cancer, and pheochromocytoma and paraganglioma (PCPG) compared to primary tumors (Figure 1E). This evidence concerns the gene ARL4C and hereditary pheochromocytoma-paraganglioma.