Prognostic network maps of VMRGs unveiled ZEB1, FLT1, EDNRB, EDN1, FLT4, PRDX2, KDR, SEMA4D, NOTCH4, DLL4, CDH5, EPHA2, MAPK1, MAPK3, and NOTCH1 as protective factors in ccRCC. The gene discussed is NOTCH4; the disease is nonpapillary renal cell carcinoma.