Prognostic network maps of VMRGs unveiled ZEB1, FLT1, EDNRB, EDN1, FLT4, PRDX2, KDR, SEMA4D, NOTCH4, DLL4, CDH5, EPHA2, MAPK1, MAPK3, and NOTCH1 as protective factors in ccRCC. Here, MAPK3 is linked to nonpapillary renal cell carcinoma.