Multiple germline mutations in TRAF7 have been reported in >50 individuals with developmental disorders mainly featuring cardiac, facial, and digital anomalies with developmental delay, suggesting a critical role for TRAF7 in early development (Tokita et al., 2018; Castilla-Vallmanya et al., 2020; Paprocka et al., 2021). This evidence concerns the gene TRAF7 and Global developmental delay.