WNT4 and cancer: It has been proved that WNT4 is usually over-expressed in multiple tumor tissues, like breast cancer,29 colorectal cancer,30 and so on, and this contributes to cancer cell differentiation and tumor progression by activating β-catenin or β-catenin-independent pathways.31 And the activation of the WNT4/β-catenin pathway contributes to EMT progression and then induces enhanced cell motility,30 which further elaborated our results that WYC-209 down-regulated the WNT4 expression, then influenced the expression of β-catenin through WNT4/β-catenin pathway, as such, inhibited EMT process.