More importantly, WNT4 overexpression caused significant reversal in the WYC-209-suppressed tumor progression because, after WNT4 overexpression, the expression of E-cadherin was decreased while the expression of N-cadherin and Vimentin were increased, while STAT3, AKT, smad2/3 as well as β-catenin were re-activated (Figure 5a, b, **P < .01, *P < .05). This evidence concerns the gene SMAD2 and neoplasm.