For example, the deubiquitinase OTUB1 is abnormally upregulated in cancer cells and promotes tumor development to suppress ferroptosis by stabilizing the cystine transporter SLC7A11, which uptakes cystine and exports glutamate.[48] DUBs promote or suppress different types of PCD, which mainly depend on downstream signaling. The gene discussed is SLC7A11; the disease is neoplasm.