It has been reported that severe and acute pyroptosis can contribute to tumor suppression, while chronic and spontaneous pyroptosis can promote tumor growth.[50] BRCC36 overexpression upregulates GSDMD expression and induces chronic pyroptosis, both of which deteriorate the tumor microenvironment (TME) over time and accelerate tumor growth, but this needs to be further studied. This evidence concerns the gene GSDMD and neoplasm.