We found that BRCC36 overexpression upregulated the expression of GPX4 and HMGCR, while decreasing the levels of 4‐HNE (4‐hydroxy‐2‐noneal), a biomarker of ferroptosis (Figure 6I,J), indicating BRCC36 inhibits ferroptosis in HCC. This evidence concerns the gene GPX4 and hepatocellular carcinoma.