In this study, we assessed the role of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\text{ER}\alpha$$\end{document}ERα-dependent TrkB-mediated neuroprotection in recognition memory, location memory and anxiety-related behavior in young adult mice after neonatal HI. The gene discussed is ESR1; the disease is Anxiety.