These results suggest that DHF therapy in \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\text{ER}\alpha$$\end{document}ERα−/− mice increased anxiety-like behavior when assessed by distance traveled and speed in open field test but decreased anxiety when assessed by freezing. Here, ESR1 is linked to Anxiety.