Studies have demonstrated a strong connection between \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\text{ER}\alpha$$\end{document}ERα and TrkB signaling in several animal models ranging from ischemic–reperfusion injury to schizophrenia, all highlighting the important role of this relationship in cognitive deficits and disability susceptibility [59, 60]. This evidence concerns the gene ESR1 and schizophrenia.