Differentially expressed genes (Additional file 1: Fig. S3C and F) were mainly enriched in apoptosis pathway (Fig. 5B, Additional file 1: Fig. S3I) and AGE-RAGE signaling pathway (Fig. 5C, Additional file 1: Fig. S3I) in AML cells treated with VEM and BOR. The gene discussed is RENBP; the disease is acute myeloid leukemia.