Compared with VEM or BOR alone, the combination significantly upregulated the upstream genes (MST1/2, LAST1/2) of HIPPO signaling pathway, thereby inhibited the expression of YAP and TAZ, 2 key genes in HIPPO signaling pathway, at the mRNA level in both AML cell lines (Fig. 5E–P). Here, MST1 is linked to acute myeloid leukemia.