Among MPNST-like samples in Group 2, the high-grade undifferentiated sarcomas were characterized by the presence of frequent chromosomal aberrations and genetic alterations, such as loss of CDKN2A/B on chromosome 9p and C19MC on chromosome 19q (Fig. 3C and Additional file 4: Table S2); while, the morphologically and clinically low-grade mesenchymal neoplasms with tyrosine kinase gene fusion had minimal or absent CNVs (Fig. 3D). Here, CDKN2A is linked to mesenchymal cell neoplasm.