These SVs, consisting of 5 frameshift variants, 1 splicing variant and 2 missense variants, were detected in 8 genes known to be associated with CHD, including KMT2D, WAC, CHD7, RAF1, EP300, GDF1, PQBP1 and LZTR1 (Table 4). This evidence concerns the gene LZTR1 and coronary artery disorder.